教育和万博ManBetX登录网页背景：

09/1999-07/2004 中国科学技术大学，生命科学学院，神经退行性疾病实验室，生物物理与分子神经生物学专业，获得理学学士学位 (五年制本科)，导师：周江宁 教授

主要万博ManBetX登录网页方向：基因多态性与疾病相关性探讨

09/2004-07/2007 中国科学院近代物理万博ManBetX登录网页所，中国科学院重离子束辐射生物医学重点实验室，生物物理学专业，获得生物物理学硕士学位 (三年制硕士)，导师：张红 万博ManBetX登录网页员

主要万博ManBetX登录网页方向：辐射增敏剂的研发  

08/2007-03/2010 中国科学院高能物理万博ManBetX登录网页所，中国科学院纳米生物效应与安全性重点实验室，实验室主任：赵宇亮 万博ManBetX登录网页员

主要万博ManBetX登录网页方向：纳米材料的生物安全性万博ManBetX登录网页

03/2010-05/2015 哈尔滨工业大学，生命科学与技术学院，生物医学工程专业，获得工学博士学位（五年博士），导师：戴志飞 教授 (北京大学工学院)

主要万博ManBetX登录网页方向：多功能造影剂的设计及研发

12/2015-至今中国科学院生物物理万博ManBetX登录网页所与北京大学分子影像与转化医学联合实验室博士后，合作导师：王凡 教授

主要万博ManBetX登录网页方向：多功能诊疗制剂设计及研发

发表论文：

1. Li X D, Liang X L, Ma F, et al. Chitosan stabilized prussian blue nanoparticles for photothermally enhanced gene delivery[J]. Colloids and Surfaces B: Biointerfaces, 2014, 123:629-638.

2. Li X D, Liang X L, Yue X L, et al. Imaging guided photothermal therapy using iron oxide loaded poly(lactic acid) microcapsules coated with graphene oxide[J]. J. Mater. Chem. B., 2014, 2: 217-223.

3. Li X D, Yue X L,  Wang J R, et al. Prussian Blue Nanoparticles Loaded Microbubbles for Photothermally Enhanced Gene Delivery through Ultrasound Targeted Microbubble Destruction[J]. Science Bulletin (Accept) 

4. Liang X L, Li X D, Yue X L, et al.  Conjugation of porphyrin to nanohybrid cerasomes for photodynamic diagnosis and therapy of cancer[J]. Angew Chem Int Ed., 2011, 50(49):11622-11627.  

5. Liang X L, Li X D, Jing L J, et al. Theranostic porphyrin dyad nanoparticles for magnetic resonance imaging guided photodynamic therapy[J]. Biomaterials, 2014, 35(24):6379-6388. 

6. Liang X L, Li X D, Jing L J, et al. Design and Synthesis of Lipidic Organoalkoxysilanes for the Self-Assembly of Liposomal Nanohybrid Cerasomes with Controlled Drug Release Properties[J]. Chem. Eur. J, 2013, 19(47): 16113-16121.  

7. Liang X L, Li Y Y, Li X D, et al. PEGylated Polypyrrole Nanoparticles Conjugating Gadolinium Chelates for Dual-Modal MRI/Photoacoustic Imaging Guided Photothermal Therapy of Cancer[J]. Adv. Funct. Mater., 2015, 25(9):1451-1462. 

8. Jing L J, Liang X L, Li X D, et al. Mn-porphyrin conjugated Au nanoshells encapsulating doxorubicin for potential magnetic resonance imaging and light triggered synergistic therapy of cancer[J]. Theranostics, 2014, 4(9): 858-871. 

9. Jing L J, Liang X L, Li X D, et al. Covalent attachment of Mn-porphyrin onto doxorubicin-loaded poly(lactic acid) nanoparticles for potential magnetic resonance imaging and pH-sensitive drug delivery[J]. Acta Biomater., 2013, 9(12): 9434-9441. 

10. Cao Z, Yue X L, Li X D, et al. Stabilized Magnetic Cerasomes for Drug Delivery[J], Langmuir, 2013, 29: 14976-14983. 

11. Yang Y B, Wang J R, Li X D, et al. A near infrared fluorescent/ultrasonic bimodal contrast agent for imaging guided pDNA delivery via ultrasound targeted microbubble destruction[J]. RSC Adv., 2015, 5: 8404-8414. 

12. Liang X L, Gao J, Jiang L D, Luo J W, Jing L J, Li X D, et al. Nanohybrid Liposomal Cerasomes with Good Physiological Stability and Rapid Temperature Responsiveness for High Intensity Focused Ultrasound Triggered Local Chemotherapy of Cancer[J]. ACS Nano., 2015, 9(2):1280-1293. 

13. Jing L J, Liang X L, Deng Z J, Feng S S, Li X D, et al. Prussian blue coated gold nanoparticles for simultaneous photoacoustic/CT bimodal imaging and photothermal ablation of cancer [J]. Biomaterials. 2014, 35(22):5814-5821. 

14. Liang X L, Deng Z J, Jing L J, Li X D, et al. Prussian blue nanoparticles operate as a contrast agent for enhanced photoacoustic imaging [J]. Chem Commun (Camb). 2013, 49(94):11029-11031. 

15. Meng H, Xing G M, Blanco E, Song Y, Zhao L N, Sun B Y, Li X D, et al. Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells[J]. Nanomedicine. 2012, 8(2):136-146. 

16. Feng S S, Wang J R, Ma F, Liang X L, Li X D, et al. Prussian Blue modified PLA microcapsules containing R6G for ultrasonic/fluorescent bimodal imaging guided photothermal tumor therapy[J]. J Nanosci Nanotechnol ( Accept) 

17. Lin L, Li X D, Yang Y B, et al. Chitosan Functionalized CuS Nanoparticles Boots Gene Transfection via Photothermal Effect[J]. (Accept)

18. Zhang H, Zhou Q M, Li X D, et al. Ginsenoside R(e) increases fertile and asthenozoospermic infertile human sperm motility by induction of nitric oxide synthase[J], Arch Pharm Res, 2006, 29(2): 145-151. 

19. Zhang H, Zhou Q M, Li X D, et al. Ginsenoside Re promotes human sperm capacitation through nitric oxide-dependent pathway[J], Mol Reprod Dev, 2007, 74(4): 497-501.

20. Zhang H, Zhang X, Yuan Z G, Li X D, et al. Germ cell loss induced by 12C6+ ion irradiation in young female mice [J] ,  J Radiat Res., 2006, 47(2): 131-134. 

21. Duan X, Zhang H, Liu B, Li X D, et al. Apoptosis of murine melanoma cells induced by heavy-ion radiation combined with Tp53 gene transfer[J], Int J Radiat Biol, 2008, 84(3): 211-217. 

22. Zhang H, Xie Y, Zhou Q M, Liu B, Li W J, Li X D. Adaptive hormetic response of pre-exposure of mouse brain with low-dose 12C6+ ion or 60Co c-ray on growth hormone (GH) and body weight induced by subsequent high-dose irradiation[J]， Adv Space Res, 2006, 38: 1148-1151. 

23. Zhang H, Duan X, Yuan Z G, Li W J, Zhou G M, Zhou Q M, Liu  B, Min F L, Li X D, et al. Chromosomal aberrations induced by 12C6+ ions and 60Co gamma-rays in mouse immature oocytes[J], Mutat Res, 2006, 595: 37-41. 

24. Zhang H, Liu B, Zhou Q M, Zhou G M, Yuan Z G, Li W J, Duan X, Min F L, Xie Y, Li X D. Alleviation of pre-exposure of mouse brain with low-dose 12C6+ ion or 60Co gamma-ray on male reproductive endocrine damages induced by subsequent high-dose irradiation[J], Int J Androl, 2006, 29(6): 592-6. 

25. 李小达,张红,高清祥,等,一氧化氮增强肝癌细胞(SMMC-7721)的辐射敏感性[J],中国组织工程万博ManBetX登录网页与临床康复, 2007, 2: 1477-1480. 

26. 李小达,张红,高清祥,一氧化氮的放射增敏作用万博ManBetX登录网页进展[J],中华放射医学与防护杂志, 2006, 6: 631 -632. 

27. 王燕玲,张红,段昕,刘兵,周清明,李小达,等,碳离子辐射对人肝癌细SMMC-7721细胞周期和P53、MDM2及P21表达的影响[J]，辐射万博ManBetX登录网页与辐射工艺学报, 2006, 24: 313-316.

28. 段昕,张红,邱嵘,高清祥,闵凤玲,郝冀芳,刘兵,周清明,李小达,等,重离子辐射提高腺病毒介导小鼠黑色素瘤细胞转染率的万博ManBetX登录网页[J],原子核物理评论, 2007, 24: 55-57.

申请的专利

1. 戴志飞, 李小达, 梁晓龙, 傅光磊, 井立佳,林丽, 杨勇博,冯珊珊. 普鲁士蓝壳聚糖复合纳米粒子作为基因载体的新应用:中国,201310711145.2013-12-20.

2. 戴志飞, 梁晓龙, 李长辉, 邓梓建,井立佳, 黄毛毛,李小达. 普鲁士蓝纳米粒子作为光声成像造影剂的新用途:中国, 201310119420. 2013-04-08.

3. 戴志飞, 井立佳, 梁晓龙, 林丽, 李小达.一种长循环硅质体及其制备方法:中国, 201410054892. 2014-02-18.

4. 戴志飞,梁晓龙,蒋灵冬,井立佳,靳玉慎,李小达.温敏复合脂质体用于水溶性及两亲性抗癌药物的控制释放:中国, 201310711063. 2013-12-20.